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Some natural anti-inflammatory agents (curcumin, resveratrol and quercetin) can act by modulating NF-B, STAT3 or MAPK signalling that may sensitize to chemotherapeutic treatments leading to protection from apoptosis when used inappropriately (210)

doi: 10.1038/s41598-020-65107-9 53 TenrioM.GracilianoN

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In the acute phase of HIV infection, the direct impact of viral replication has been shown to significantly contribute to the initial loss of CD4+ T cells via: (i) the increased permeability of the cell membrane after viral budding and/or syncytium formation resulting in cytolysis, (ii) the induction of HIV-specific CD8+ cytotoxic T lymphocytes, which target and eliminate virally infected cells, and (iii) the programmed cell death of cells undergoing productive infection due to caspase-3 and/or Bax activation [11]