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after a median of 12.4 years of monitoring, those in the highest quartiles of baseline CAC scores and carotid artery plaque burden had 15% and 23% higher risk of death for any reason, respectively, compared with those in the lowest quartiles

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Evidence has shown that 8 weeks of aerobic exercise significantly activates the System Xc /GPX4 signaling axis in the prefrontal cortex of AD mice, upregulates ferritin light chain (FTL) and -site amyloid precursor protein cleaving enzyme 1 (BACE1), downregulates 4-hydroxynonenal (4-HNE), inhibits ferroptosis and lipid peroxidation, and ameliorates cognitive deficits (Li et al., 2024a)

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doi: 10.1007/s11010-007-9563-x

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