U-42126Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a -glutamyl transpeptidase (GGT) inhibitor
The mechanism of action involves targeting mitochondrial complex I and ATP synthases, leading to a partial reversal of resistance ( 3 Lipid metabolism Adipocytes and the tumor microenvironment formed with the participation of adipocytes have a very important impact on the occurrence, development, and prognosis of malignant tumors ( 3.1 -oxidation Fatty acid -oxidation has been linked to platinum resistance ( 3.2 Fatty acid binding protein 4 In the context of ovarian cancer, FABP4 plays a central role in regulating adipocyte-induced lipid metabolism in cancer cells ( 3.3 Cholesterol Cholesterol metabolism dysregulation can be a contributing factor to platinum resistance in ovarian cancer, as cholesterol is a vital component of cell membranes and plasma lipoproteins and a precursor for important bioactive molecules ( 4 Amino acid metabolism Assays of serum-free amino acids have shown that the levels of many amino acids change significantly during the development of ovarian cancer and that this change in turn promotes tumor development ( 4.1 Glutamine Glutamine, the most abundant non-essential amino acid in the human body, serves a multitude of purposes, including its function as a key substrate or molecule in the biosynthesis of various compounds, and its essential role in maintaining normal cellular function and integrity ( 4.2 Glutathione GSH is synthesized from glutamic acid, cysteine, and glycine and is one of the important members of cellular antioxidants ( Figure 2 )
VanLandingham JW, Cutler SM, Virmani S, Hoffman SW, Covey DF, Krishnan K, et al
Glutathione: antioxidant properties dedicated to nanotechnologies Antioxidants (Basel)
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Results Physiological and antioxidative responses to 5-oxp application for perennial ryegrass under non-stress and heat stress conditions Plants treated with 5-oxp demonstrated more vigorous turf growth and greener leaves in comparison to untreated plants under heat stress, as demonstrated in Fig
