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NADPH acts as a competitive inhibitor, while NADP + is both a substrate and a structural activator, stabilizing the enzymes active conformation by binding to a regulatory site near the dimer interface, helping to maintain the dimeric (active) structure

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The melanocortin system interfaces with the hypothalamic-pituitary-adrenal (HPA) axis, which means hormonal effects are expected, not incidental

doi: 10.3389/FPHYS.2019.01038 228 GuoY-JPanW-WLiuS-BShenZ-FXuYHuL-L

We're part of a multi-institutional ARPA-H-funded project where we're trying to regenerate the cartilage in osteoarthritis patients