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To study the interaction, 200 ng/l dsDNA incubated for 24 h at 37C, 100 rpm, in either absence or presence of 1 mM GSH at intrinsic pH or 1 mM GSH at neutral pH (7.2)

doi: 10.1016/j.cmet.2020.10.011, 124

doi: 10.1038/s41598-022-11236-2 Summary Keywords metformin, rectal cancer, colorectal, radiosensitiser, energy metabolism, radioresistance Citation Buckley CE, OBrien RM, Nugent TS, Donlon NE, OConnell F, Reynolds JV, Hafeez A, ORordin DS, Hannon RA, Neary P, Kalbassi R, Mehigan BJ, McCormick PH, Dunne C, Kelly ME, Larkin JO, OSullivan J and Lynam-Lennon N (2023) Metformin is a metabolic modulator and radiosensitiser in rectal cancer

Spreading depression triggers headache by activating neuronal panx1 channels

Taking it on an empty stomach helps absorption but might cause stomach issues

Meanwhile, downregulation of miR-218 was proved effective in suppressing central neuropathic pain via regulating cytokine signaling (Li and Zhao, 2016)