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Electrophysiology experiments further demonstrated that GLP-1R activation led to depolarization of POMC neurons and inhibition of NPY/AgRP neurons, mediated by GABAergic signaling, explaining the suppression of hunger signals

Geronzi et al., 2018)

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These factors can make it harder for people to tolerate nutrient-dense foods consistently

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For patients with unusual weight (such as morbid obesity), it may be helpful to check a phenobarbital level 2 hours after the initial loading dose (to confirm an adequate level was achieved and to calculate V D )