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10.1016/j.matbio.2015.02.002 18 HuangC.DengJ.HuangW.JiangW.HuangG

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6.3 Site-specific metabolism: blood cells The observation of a facilitated uptake of 5-(3,4-dihydroxyphenyl)--valerolactone into blood cells and its determination in cell samples of osteoarthritis patients after intake of Pycnogenol (see section 5.2 Distribution into blood cells) prompted systematic advances to elucidate the detailed metabolism of 5-(3,4-dihydroxyphenyl)--valerolactone in human blood cells (28)