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People who have persistent GI side effects at 8mg often make the pragmatic choice to maintain that dose rather than escalate further

Many studies have investigated the potential correlation between genetic background and hypogonadal dysfunction in individuals with PWS, but no data have shown an impact of the various genetic defects (such as 15q11-13 paternal deletion, mUPD, or imprinting defect) on pubertal development and fertility (203, 204)

251,255 p53 loss alleviates changes in mHtt expression and mitochondrial dysfunction and prevents neuronal degeneration to relieve some of the neurobehavioral defects associated with HD