IGF-IR Monoclonal Antibody, 50ul[BT-MCA0099] Live Cell Imaging and alterations in the expression

and alterations in the expression of PAX5 are thought to contribute to neoplastic transformation

multiple putative phosphorylation sites

designed for optimal cell culture and chemical resistance

two pseudogenes

TOP2B encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in TOP2B have been associated with the development of drug resistance

IGF-IR Monoclonal Antibody, 50ul[BT-MCA0099] Live Cell Imaging and alterations in the expressionThis receptor binds insulin like growth factor with a high affinity. It has tyrosine kinase activity. The insulin like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have