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Real-world data from compounded tirzepatide patients shows similar outcomes (14.2% weight loss at 72 weeks in a 2025 retrospective cohort, though this was not a controlled trial and patient populations differ)

Contact your GP if weight gain persists despite good medication adherence and lifestyle measures, or seek urgent medical attention if you experience severe abdominal pain, persistent vomiting, jaundice, or sudden breathlessness with leg swelling

You get real clinical support, not a generic protocol

These non-standard doses are not available in brand-name pens but are easily achieved with compounded vials and a syringe

How to make tirzepatide work better

Efficacy and safety of once-weekly semaglutide versus once-daily sitagliptin as an add-on to metformin, thiazolidinediones, or both, in patients with type 2 diabetes (SUSTAIN 2): a 56-week, double-blind, phase 3a, randomised trial