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Prolyl-Fluoropyrrolidine In a study by Wang et al., a new range of 4-fluoropyrrolidine-2-carbonitrile and pyrrolidine-2-carbonitrile derivatives was designed, with compound 36 identified as the most effective and selective DPP-4 inhibitor (109)

Deprs-Brummer, P., Bourin, P., Pages, N., Metzger, G

The -MSH trigger signal activates ERK after phosphorylation of MEK by cAMP, and p-ERK promotes MITF degradation and inhibits melanin production (Shirasugi et al., 2010

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2008 Mole SE, Williams RE, Goebel HH: Correlations between genotype, ultrastructural morphology and clinical phenotype in the neuronal ceroid lipofuscinoses