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To overcome the difficulties in targeting NRF2 for controlling NRF2-addicted cancers, targeting metabolic liabilities unique to NRF2-addicted cancer cells, such as dependency on exogenous NEAAs, including glutamine, is a very sensible way to achieve selective toxicity toward cancers that have fallen in NRF2 addiction

doi: 10.1007/s12035-024-04593-8

At 60 h-post injection, the mice were sacrificed and the biodistribution determined upon fluorescence imaging of the respective organs

Choline prevents cholesterol buildup

Imbalances in serum iron homeostasis can trigger inflammation and gut microbial diseases, leading to brain stress responses

However, kefir production faces limitations, including microbial variability, short shelf life, and high processing costs