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A separate analysis of patients who were carnitine-deficient at baseline did not show statistically significant improvement in fatigue or other outcomes after L-carnitine supplementation

Its a little bit of a chicken-and-egg-type situation, said Stacie Dusetzina, a health policy professor at Vanderbilt University Medical Center in Tennessee

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Nevertheless, since both metabolites are associated with vascular dysfunction and both are produced in mice and humans following L-carnitine challenge, studying these compounds will allow for an examination of their role in the cerebrovascular dysfunction associated with E4

These are pleiotropic effects that go well beyond what you would predict from weight loss or glycemic improvement alone