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Denys 2009)

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As a consequence, the function of electron transport chain complexes I, III, and IV is impaired, and pro-apoptotic factors such as cytochrome c, SMAC/DIABLO, and apoptosis-inducing factor (AIF) are released into the cytosol

Considering that CVS is a multifactorial disease, each patient should have a psychologic evaluation to evaluate the level of anxiety and dysautonomic signs during the crisis should be systematically screened to determine the optimal prophylactic treatment