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TB-500 (Thymosin Beta-4 Fragment) TB-500 is a synthetic fragment (amino acids 1723) of Thymosin Beta-4, the body's primary actin-sequestering peptide

TB-500's primary mechanism is upregulating actin, a protein essential for cell structure, movement, and repair

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Lee EK, Gorospe M: Minireview: Posttranscriptional regulation of the insulin and insulin-like growth factor systems

PMID: 32257855

Essentially, the intestinal barrier plays the role of a gatekeeper , and a special protein called Zonulin is what determines how open or closed these gates, known as tight junctions , should be