tirzepatide parkinson Real-World Use of GLP-1s Yields Less Weight Loss Than Clinical Trials Is it time to repurpose

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Despite these potential challenges, the inclusion of participants with OSA and OA through basket studies in an obesity clinical development program allows for greater representation of selected demographic groups

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The clear dose-response pattern mirrors findings from the SURMOUNT trials, where escalating tirzepatide doses led to progressively larger weight losses [16,19], and aligns with prior meta-analytic evidence demonstrating greater efficacy at higher fixed doses of tirzepatide in non-diabetic adults [5]