GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 size:10mg solid Sharlow ER
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GNF7156, β Cell Proliferation Inducer - CAS# 2041071-54-7 size:10mg solid Sharlow ERGNF7156, CAS No. 2041071 54 7, is a highly potent and selective small molecule that promotes pancreatic cell proliferation in rodent EC50 ~2. 2 Mand human primary islets (EC50 ~0. 76 M). It acts most likely as a result of combined inhibition of DYRK1A and GSK3B. GNF7156 treated human islets retain functionality in vitro and after transplantation into diabetic mice. Oral dosing of GNF7156 in diabetic mice induces cell proliferation, increases cell mass
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