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Collectively, these findings raise the possibility that the mechanism of glucocorticoids increasing serum IGF-I levels is by directly inducing post-IGF-IR signaling resistance

These findings underline the importance of interdisciplinary cooperation in the treatment [of] rosacea, the authors write.

What the mechanism does NOT prove: A mechanism observed in vitro or in rodents does not predict the magnitude, durability, or route-dependence of clinical benefit in humans