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Five independent biological experiments were performed

doi: 10.3389/fimmu.2013.00105

And I wonder whether or not the discomfort of cold, deliberate cold exposure, and the discomfort of heat might be anchoring to the same pathway

Firstly, they demonstrated that the human brains from APOE4 carriers show increased intracellular accumulation of cholesterol, fewer myelinated axons, and thinner myelin sheaths in comparison to age-matched non-carriers [78]

Heidari R, Ghanbarinejad V, Ommati MM, Jamshidzadeh A, Niknahad H, Mohammadi H, Sayad A, Mohammadi M, Niknahad H, Heidari R (2020) N-acetyl cysteine treatment preserves mitochondrial indices of functionality in the brain of hyperammonemic mice

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