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Exenatide LAR exhibited better or noninferior efficacy in lowering HbA1c than most active comparators (except liraglutide and pioglitazone) in the DURATION program [69]

Though several molecules, such as mazdutide, a GLP/glucagon dual agonist, are being studied in various phases, the first agent targeting incretins other than just GLP-1 was approved in 2022 tirzepatide [41]