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study used intra-articular injection under clinical supervision

Innate or adaptive immunity

A decrease in phagocytosis, as well as ERK1/2 phosphorylation, was also seen in in response to dopamine (2 10 6 M) treatment of LPS-activated BV2 microglia, but no effect on the phagocytic activity of resting cells was observed, suggesting autocrine control of phagocytosis by dopamine signaling in activated myeloid cells (Fan et al., 2018)

It even helps reduce gut inflammation by suppressing pro-inflammatory signalling pathways

In both vivo and vitro models, acetate exhibited anti-neuroinflammatory activity by suppressing microglial activation, reducing the expression of inflammatory proteins, oxidative stress markers, and signaling molecules in the hippocampus (Wen et al., 2020)