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All cited studies are conducted in rodent or in-vitro systems consistent with RUO classification

clostridioformis and secondary BA production, compromising the therapeutic response to PD-1 blockade (172)

Madsen CD, Pedersen JT, Venning FA, Singh LB, Moeendarbary E, Charras G, Cox TR, Sahai E, Erler JT (2015) Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

10.1111/jdi.12650 74 SunW.Li (2003)

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Clinical testing of the prodrug determined that despite reasonable kidney specificity it had low bioavailability (Lee, 1990)