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Nature medicine 19, 576585 (2013)

doi: 10.1146/annurev.pathol.1.110304.100125 7 AurassP.SchlegelM.MetwallyO.HardingC.R.SchroederG.N.FrankelG.et al (2013)

A: Yes, it works well as a base before lipstick application

Phase 2: weeks 5 through 12 (building momentum) By week five, most people have adapted to the initial dose and gastrointestinal side effects have diminished significantly

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But when weight loss occurs rapidly particularly without adequate nutrition and physical activity individuals may lose not only fat, but also lean muscle mass and bone density