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Small-molecule inhibitors of protein-protein interactions: progressing toward the reality

Zhu J, Zhang Y, Zhang W, Zhang W, Fan L, Wang L, Liu Y, Liu S, Guo Y, Wang Y, Yi J, Yan Q, Wang Z, Huang G

Wegovy, Saxenda and Zepbound are approved for weight loss in the following individuals: Adults with an initial BMI of 30, defined as obesity Adults with an initial BMI of 27, defined as overweight, with at least one weight-related comorbid condition Weight-related comorbid conditions include high blood pressure, cardiovascular disease (such as coronary artery disease, heart attack or heart failure), high cholesterol, obstructive sleep apnea, type 2 diabetes, fatty liver, GERD/acid reflux, osteoarthritis, urinary incontinence, etc

Elevated intracellular cAMP activates protein kinase A (PKA), which phosphorylates the cAMP response element-binding protein (CREB), driving transcription of melanogenesis-related genes including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT) in melanocyte models

Are there specific blood tests (like thyroid, iron, or hormone panels) we should run to rule out other causes

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