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In vitro, PNA splenocytes and MLNs had reduced IL-5, IL-4, IL-13, and IL-10 production while IFN- was significantly increased upon B-FAHF-2 treatment [30]

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Therefore, the reduced capacity to carry out the methionine synthase reaction, due to nutritional or disease mediated deficiency of vitamin B12, results in reduced SAM production and as a consequence contributes to the neural degeneration (i.e