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Tissue homogenates were centrifuged at 12,000 g for 15 min at 4 C, and the supernatants were collected

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Methionine is then converted into S-adenosylmethionine, which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine that is converted back into homocysteine