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In addition, the oxidative damage induced by excessive ROS and decreases in antioxidants, such as superoxide dismutase and glutathione peroxidase in diabetes also causes mitochondrial dysfunction (63)

Key pathways influenced include PI3K/Akt and MAPK, which control protein synthesis, nutrient utilization, and cell division

Obesity and CD8 T cell metabolism: implications for antitumor immunity and cancer immunotherapy outcomes

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