Stat3 Polyclonal Antibody, 100ul[BT-AP01663] Purification Dual specificity protein phosphatases inactivate

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues

The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2

In mammals

This protein is localized in the nucleus and contains an E1A-type zinc finger domain

online information:Core 2 beta-1

Stat3 Polyclonal Antibody, 100ul[BT-AP01663] Purification Dual specificity protein phosphatases inactivateThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors STAT family members are phosphorylated by the receptor associated kinases and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs EGF IL5 IL6 HGF LIF and BMP2.