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The most common issue among Legacy patients is dry mouth, he notes

March 2026: Novo Nordisk reported top-line REDEFINE-1 Phase 3 CagriSema data showing 22.7% mean body weight reduction at 52 weeks , demonstrating superiority over standalone semaglutide 2.4mg and confirming the semaglutide-plus-amylin combination as clinically competitive with tirzepatide

These drugs work as appetite suppressants, helping patients regulate food intake by reducing feelings of hunger, and they are one of few medications able to reliably induce long-run weight loss and its downstream health benefits

doi: 10.1111/DOM.12251 33 MatsumuraKSugiuraT

The weight loss advantage of retatrutide over tirzepatide appears to be approximately 6 percentage points at the highest doses, a clinically meaningful difference