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3.7.3 Environmental resilience and metabolic synergy Survival and delivery are optimized through distinct physiological traits

Its primary role is to neutralize free radicals, detoxify the body, and support the immune system

Gut dysbiosis-induced overproduction of LPS and peptidoglycans potently activates innate immune receptors, driving systemic inflammation that can breach the BBB and exacerbate neural damage (Kesika et al., 2021)

Drugs Aging 39 , 829840 (2022)

By upregulating antioxidant defenses and phase II detoxification enzymes, Nrf2 helps mitigate the oxidative and electrophilic stress induced by these toxins, protecting the liver and maintaining its functional integrity (Figure 2) (Table 2)

The exact mechanisms are likely multifactorial, Rosenzveig explained to MNT