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Estrogen plays a critical regulatory role in osteoclastogenesis primarily through modulation of the RANKRANKL signaling pathway

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As the c-Jun/ATF2 heterodimer induces transcription of many genes such as Cyclin D1 , Cyclin A , c-Jun and Atf3 , 37 changes in JNK activation most likely contributes along with ERK1/2 signaling alterations to the delay in G1-to-S phase progression in Gstp1/2 / mice

Rev Cardiovasc Med 23(3):108 Ammash NM, Seward JB, Bailey KR, Edwards WD, Tajik AJ (2000) Clinical profile and outcome of idiopathic restrictive cardiomyopathy