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Weight loss is 12.4% in trials (vs 15-22% for injectables), but self-pay pricing is significantly lower ($149-$349/month vs $1,000+/month for injectables)

Gastrointestinal adverse effects, including nausea and vomiting, remain the most commonly reported side effects and may influence adherence during treatment initiation

Holmes GM, Browning KN, Tong M, Qualls-Creekmore E, Travagli RA

After years of use in practice, we use it in time-boxed, medically supervised courses (up to 12 months) with clear goals and monitoring

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In addition to the previously discussed nutrient-sensing and autophagy pathways, the molecular landscape of inflammaging further encompasses several key regulatory signaling pathways: the cGAS-STING, Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathways, Wnt/-catenin signaling, and Notch signaling