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Mood Changes and Depression: Although some studies point to antidepressant effects, some individuals may experience negative mood changes, including the onset or worsening of depressive symptoms

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Competitive Inhibition and VMAT Reverse Transport : Amphetamines are also recognized as substrates by VMAT2 and actively compete with endogenous dopamine for vesicular uptake, further inhibiting normal dopamine storage (Wimalasena 2011)