HP1 gamma(Phospho-Ser83) Rabbit Polyclonal Antibody, 20ul Custom Peptide Synthesis Multiple alternatively spliced transcript variants

Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria

This gene has been referred to as rpL23 because the encoded protein shares amino acid identity with ribosomal protein L23 from Halobacterium marismortui

Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy

Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2)

not all variants have been fully characterized

HP1 gamma(Phospho-Ser83) Rabbit Polyclonal Antibody, 20ul Custom Peptide Synthesis Multiple alternatively spliced transcript variantsAt the nuclear envelope the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone