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Safety and Clinical Management Safety trials of GLP-1 RAs, including liraglutide, tirzepatide, and semaglutide (oral or subcutaneous), indicate that the most common adverse events (AEs) of treatment are mild to moderate gastrointestinal including nausea, vomiting, diarrhea, constipation, dyspepsia, and decreased appetite

10.1038/aps.2018.37 40 ZhangQ.HuL.LiH.WuJ.BianN

It is typically identified through a combination of symptoms and functional medicine testing such as the lactulose-mannitol test, zonulin level testing, comprehensive stool analysis, and a detailed review of personal health history to determine underlying causes and guide treatment