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Chronic inflammation is another key player

The increases in their expression can impact AR in a variety of manners, including stabilization of AR mRNA through RNA-RNA hybridization (ARLNC1 [117]), absorption of miRNAs (plncRNA-1 [118]), facilitation of mRNA splicing (PRKAG2-AS1, HOXC-As1 [119]), interference with epigenetic control over AR target genes (SOCS2-AS1 [120]), preventing AR degradation (HOTAIR [121]), regulating its binding to chromatin (PCAT1 [122]) or binding to AR and thereby enhancing its transactivation (PCAT8, PCGEM1 [123])

doi:10.1016/j.ymben.2005.06.001

But remember that your genes are not your destiny

Results 621 annotated metabolites clustered into eight metabolite modules, of which one, the acylcarnitine module, was significantly inversely associated with depressive symptomatology ( = 27.7 (95% CI ( 54.50.8)