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Semaglutide and other GLP-1 medications have been shown in clinical trials to raise heart rate in some patients, typically by 2-5 beats per minute on average

The dosing schedule begins with a small introductory dosage of 0.25 mg and is increased slowly until a therapeutic dosage (a dose which provides good hunger suppression, minimal side effects, and consistent weight loss) is reached or the highest FDA-approved dose, 2.4 mg, is reached