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Some practitioners theorize that establishing robust GLP-1-supporting gut bacteria before discontinuing medication could provide a partial buffer against rebound effects, maintaining some degree of natural GLP-1 production even after the pharmaceutical support is removed

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Whilst PT-141 is a variant of Melanotan, Melanotan 2 is primarily researched for tanning it may have indirect effects on libido due to its melanogenesis-stimulating properties, whereas PT-141 directly targets sexual function by activating melanocortin receptors in the brain