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Walsh LA, Quail DF

Most patients had comorbid pathology [hypertension, cerebrovascular diseases (CVDs), cardiovascular disease, and diabetes] and had been mentally ill for many years/decades (Table 1)

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Based on the single dose tested for 2 , the estimated ED 50 is below 100 mg/kg

Preclinical studies suggest it could have applications in Alzheimers disease, dementia, Parkinsons disease, and traumatic brain injury, while biohackers and peptide researchers are exploring it as a nootropic for memory and learning enhancement

In order to further characterize this effect, -Glu-Glu was then tested on cells expressing either of GluN1 and GluN2A or GluN1 and GluN2B NMDAr subunits, bearing in mind that they are the most abundant NMDA receptors found in the hippocampus ( NMDA receptors were expressed first in astroglioma C6 cells