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O., Vidal-Peracho, C., Hidalgo-Garcia, C., Rodriguez-Sanz, J., Tricas-Vidal, H., Hernandez-Secorun, M., et al

SCD pathophysiology In sickle cell disease, beta-globin, a component making up 50% of the Hb, has a genetic mutation

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Therefore, hyperhomocysteinemia-induced immunoinflammatory disorders and abnormal immune response may aggravate abnormal immunoinflammatory in PD, leading to more progression of PD severity

Chambers BI

Furthermore, microbial metabolites like SCFAs can indirectly activate the vagus nerve by stimulating EECs to release multiple hormones, such as 5-HT and GLP-1