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A study conducted using purified oligodendroglial cultures at various developmental stages has demonstrated that high concentrations of A oligomers can significantly decrease the survival of mature oligodendrocytes [70]

Due to this high risk, women of childbearing age should use strict birth control methods to avoid becoming pregnant while taking isotretinoin

Normal circulatory support for tissue nourishment*2,4,6

Vitamin D3 injections may be prescribed with levels lower than 40

The prescription-only status further ensures that a medical professional oversees their use and monitors outcomes to maintain safety

Pulsed administration may also reduce off-target effects on non-senescent cells