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the AGE-RAGE signaling, which induces axonal atrophy through p38 MAPK activation (Sango et al., 2025), and the PKC- activation, which impairs nerve blood flow via endothelin-1 overexpression (Chong and Souayah, 2025)

Diabetes 42, 16781682 (1993)

This data extraction sheet included the following information: authors, publication year, journal name and the journal quartile ranking, country, and setting of the study, study objectives, inclusion/exclusion criteria, sample size, patients characteristics, intervention and comparator description, sample size, duration, follow up, study outcomes, major findings, and study conclusion

The most significant weight loss usually occurs between 6 and 12 months of continuous use

Heme degradation in the presence of glutathione

Tilling, I.R