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In vitro study using human vascular endothelial cells further confirmed the increased mRNA and protein expressions of VEGFR2 but not VEGF-A

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After transplanting T315I-Bcr-Abl-32D/EGFP cells into C3H/HeNCrNarl mice for 7 days, the mice were treated with daily intraperitoneal injections of UK-5099 alone or in combination with JMF4073 for 14 days (Fig