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Pharmacological management options: According to the American College of Gastroenterology (ACG) guidelines, an 8-week trial of once-daily proton pump inhibitors (PPIs) such as omeprazole or esomeprazole is recommended as first-line therapy for typical reflux symptoms without alarm features

for example, it produces greater average weight loss at 3, 6, and 12 months compared to semaglutide (Ozempic variants)

Accessed 27 May 2024 Gudzune KA, Stefanski A, Cao D, Mojdami D, Wang F, Ahmad N, Ling PJ

Even people in clinical trials had to follow a nutritious, balanced diet and maintain a 500-calorie deficit