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Regulatory status (US) FDA-approved prescription drugs These compounds work through different mechanisms and are not interchangeable

It has been demonstrated that GSH depleted astrocytes lose their neuroprotective roles, leading to neuronal toxicity and a consequent reduction in cell viability (Pizzurro et al., 2014a,b)

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Nrf2 also regulates the expression of proteins participating in phase II detoxification processes carried out by glutathione-S-transferase and involves the association of glutathione (GSH) with xenobiotics and/or toxic materials (97)

The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance

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